Last week, the White House issued an executive order, Launching the Genesis Mission, introducing a national initiative to harness AI and strengthen the U.S. technological edge.

The EO directs the development of an integrated AI platform that utilizes federal scientific data to train models, validate hypotheses, and speed breakthroughs on complex and critical challenges. Ultimately, the intent of the Genesis Mission is to “dramatically accelerate scientific discovery, strengthen national security, secure energy dominance, enhance workforce productivity, and multiply the return on taxpayer investment into research and development, thereby furthering America’s technological dominance and global strategic leadership,” according to the EO’s release.

Examples of science and technology challenges the Genesis Mission will seek to address include those in advanced manufacturing, biotechnology, critical materials, nuclear fission and fusion energy, quantum information science and semiconductors and microelectronics.

Specifically, the American Science and Security Platform, is slated to be built and maintained under the Department of Energy, created as a closed-loop AI platform leveraging the department’s supercomputers and scientific assets. For its part, the President’s Office of Science and Technology Policy will oversee the coordination and integration of enterprise federal data and infrastructure to the platform.

Opportunities exist for industry partners to assist DOE in establishing and operating the platform, including providing cloud-based high-performance computing systems, computing, storage, and networking resources, and AI frameworks to evaluate outcomes and automate workflows, to name a few.

Within 90 days of the order, DOE is tasked with assessing the resources available through industry partners and any additional partnerships to support the foundation and infrastructure of the platform. Thereafter, 120 days from the order, DOE will identify a set of initial data and models for use, and by 270 days demonstrate an initial operation capability of the platform for at least one national science and technology challenge.

AI Data Center and Energy Infrastructure Development

The Genesis Mission is not the only national AI initiative the DOE is turning to contractor support for – the agency is also leading the Trump Administration’s efforts to accelerate and expand AI data centers and energy generation projects at select DOE sites. In July 2025, DOE announced the selection of four sites for data center and energy infrastructure construction: Idaho National Laboratory, Oak Ridge Reservation, Paducah Gaseous Diffusion Plant and Savannah River Site. The department has since issued solicitations for each site seeking support to build and power the AI data centers.

As the Trump Administration advances key elements of the AI Action Plan into 2026, particularly the development of American AI infrastructure, contractors should closely monitor federal and agency-level initiatives to align strategies with evolving government priorities.